The problem with the Universe is NOT...

'The problem with the Universe is
NOT that it DOESN'T make sense, but
rather that it ALMOST makes sense.. ' - Lord Rutherford

What do people think about this quote?

People, especially scientists, will always try to make sense out of the universe and the world around the. Things do have a "pattern" or a "flow" to them. However, as string theory which suposely helps unify many physics theories into one, things become only thought with no real basis. As I have said before: There is no existence trully percievable by itself.

And so the quote to me means that though the universe does indeed make sense... we will never understand it.

universe makes perfect sense

What was he referring to when he said "universe"?

I think what we know about the Universe means it has to make some sort of sense... One thing that complicates it is to just about every quality there is an anomele where normally 'this is true for all things, except in the case of...'
But as the Universe is so large and complicated, it would take forever just to fully understand just one second of what is going on...
Just think of a clear memory, 'how many different things can you say were going on in that memory?'... the answers will end up being so long that it will seem almost impossible to live through a situation and know exactly what was going on...
I guess the Universe does make complete sense, we're just not within our senses enough to make that much sense of it all...

If you new everything the universe would make sense. Its not necessarily what we do now nowadays; but what we don't know that muddles us up. Mind you; it always has been I suspect. And it depends whether your hungry for that void of the unkown or if you want to set yourself up as prey for the unkown. My quote reads mystery starts most things; I was only someway right;

'Mystery can either strart things or make you stagnate"

The universe makes perfect sense, like everything, it all runs to a set of rules, it grows, matures, serves it's purpose, dies and gets recycled. Just think, birth, life, death as with everything else living, just on a somewhat bigger scale!